Targeting Two SARS-CoV-2 Proteases for Drug Discovery Effort

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Project contact: Robert Stroud

PI: Robert Stroud

Funding: NIDDK

Public Summary

crystallize the two proteases, and develop drugs using three methods based on iterative structure based methods, fragment screening, computer docking followed by crystallography and iterative improvement, and tethering technologies that insert cysteine residues as a 'fishing line' to select sulfhydril compounds that bind well there, and elaborate them!

Type of Research: Basic Science study

Topics: Research Tool Development, Treatments, Drug Development, Drug Repurposing, Drug Treatment