Design of hyper-stable de novo proteins as viral entry inhibitors

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Public Summary

The Kortemme laboratory pursues de novo designed proteins - proteins engineered computationally from scratch - for blocking SARS-CoV-2 entry into human cells by targeting the virus' "spike" protein. De novo designed proteins are a new class of potentially highly stable and potent therapeutic molecules. We are also interested in developing a general computational and experimental platform for rapidly generating de novo proteins that could be impactful beyond the current crisis.