This Funding Opportunity Announcement (FOA) invites applications for Clinical or Community Field Centers (CCFC) to establish a new population-based cohort study to address key population research gaps in the health of Asian Americans (AsA), Native Hawaiians, and Pacific Islanders (NHPI). This epidemiological cohort study will enable the enrollment, initial examination, and follow-up activities of a cohort of approximately 10,000 participants from multiple immigrant generations of ancestral Asian subpopulations, as well as, Native Hawaiians, and Pacific Islander subpopulations. Specifically, this initiative will utilize a “populomics” perspective, i.e., examination of health influences across multiple levels (biological, lifestyle/behavioral, environmental, sociocultural) using multi-disciplinary methods to investigate the web of influences impacting the health of AsA-NHPI subpopulations.

This FOA uses the bi-phasic, milestone-driven cooperative agreement mechanism (UG3/UH3) and runs in parallel with a companion FOA (RFA-HL-23-016) that encourages applications for a Coordinating Center (CC). Awards made under this FOA will support a milestone driven planning phase including feasibility studies and pilot activities for up to two years (UG3), with possible transition to an implementation phase (UH3) for up to five additional years. Only UG3 cohorts that meet the scientific milestones and award requirements of the UG3 may transition to the UH3 phase. Applications submitted to this FOA must address both the UG3 and UH3 phases. Applications must also include plans for study participant recruitment and retention, scientific conduct of the study including a clinical examination, data collection, follow-up contacts, coordination with the CC and performance milestones for each phase.