NIOSH/CDC invites applications for the NIOSH Centers of Excellence for Total Worker Health (TWH). The purpose of this FOA is to solicit meritorious applications for Centers of Excellence for TWH to develop and conduct a broad range of multidisciplinary research, intervention, outreach and education, and evaluation activities that advance the overall safety, health, and well-being of the diverse population of workers in our nation. Center structure should take advantage of diverse scientific resources and focus on local, regional, or national worker safety and health issues. Centers should emphasize creating and implementing evidence-based solutions to address evolving challenges and opportunities related to worker safety, mental and physical health, and well-being. Collaborations in partnership with academic institutions, nonprofit organizations, and other groups focused on occupational safety and health are expected. Applicants must concisely describe the occupational health burden within their service area and directly link research and outreach activities to help alleviate the burden. Applicants should also clearly articulate the anticipated impacts of the proposed work, both during the project period and beyond.