The purpose of this Special Emphasis Notice (SEN) is to inform the research community of the Agency for Healthcare Research and Quality (AHRQ) continued interest in, and available funding for, supporting innovative research seeking to reduce the burden of healthcare-associated infections (HAIs) and to address the growing threat posed by antimicrobial resistant organisms. HAIs continue to cause significant patient harm and are also associated with considerable financial consequences for healthcare facilities and for patients. Unfortunately, the COVID-19 pandemic has been associated with observed increases of several types of HAIs as well as increases in antimicrobial resistance, highlighting the importance of developing and studying resilient and adaptable countermeasures.
AHRQ will continue to support applications submitted in response to HAI Prevention (R01 and R18) and Combating Antimicrobial Resistant Bacteria (R01 and R18) Notices of Funding Opportunities (NOFOs). Applications utilizing clinical trials, rigorously designed observational studies, or applied health services research are encouraged. AHRQ is particularly interested in addressing knowledge gaps regarding care and outcomes seen in diverse populations, especially AHRQ’s priority populations. AHRQ is committed to advancing health equity and intends that research funded by the agency contribute to the goal of improving health equity. AHRQ encourages applicants responding to these NOFOs to consider whether their proposed projects could include interventions or analyses to advance health equity and, where relevant, to address these issues in the proposed research plan. In addition, AHRQ is interested in research conducted in a variety of healthcare settings including acute care hospitals, long-term care, and ambulatory care settings, as well as transitions between care settings. As HAI prevention and combating antimicrobial resistance efforts are less well-developed in long-term care, ambulatory settings, and transitions between settings than in acute care, applications addressing these less developed settings are of particular interest. There are numerous opportunities for research across a broad range of topics.
Applications studying healthcare delivery that directly benefit patient outcomes, contribute to the understanding of HAIs, and improve healthcare delivery are most suitable for the listed NOFOs. Applications that investigate the appropriate integration of FDA-approved diagnostic or therapeutic modalities into clinical care are encouraged. However, applications that include the use of diagnostic tests or therapeutic agents that are not yet FDA-approved are generally not appropriate for AHRQ funding.