Funder: NIH: National Institute of Dental and Craniofacial Research (NIDCR)

The National Institute of Dental and Craniofacial Research (NIDCR) is reissuing this Notice of Special Interest (NOSI) to encourage research studies focused on the physiological involvement of oral cavity and oral manifestations related to SARS-CoV-2 and/or Coronavirus Disease 2019 (COVID-19).

As the pandemic continues to evolve and new viral variants continue to emerge the need to fill knowledge gaps and for a better understanding of SARS-CoV-2 remain. A major unmet clinical need has arisen to block the transmission chain, prevent frequent breakthrough infections, and achieve high levels of durable protection against severe disease, no less prevent post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID). NIDCR is positioned to address COVID-19 research knowledge gaps unique to our mission, as well as to facilitate broad and rapid dissemination of research findings. Outcomes from this NOSI are expected to strengthen the knowledge base of COVID-19 disease mechanisms and presentations in the oral cavity.

Topics: Antibody, Biomarkers, Clinical Presentation of Infection, ARDS, Cellular / Molecular Response, Inflammation, Long-term Impact of Infection, Pneumonia, Sensory, Clinical Trial, Co-Morbidities, COPD, COVID-19, Gastroesophageal Reflux Disease (GERD), Hidradentis Supporativa, Immune Disorders, HIV, Immunosuppression, Inflammation, Neurological Disorders, Substance Abuse, Computational or Data Science Methods Development, Diagnostics, Economic Impact, Environmental Health, Epidemiology, Clinical History, Clinical Outcome, Risk Factors, Transmission, Aerosol, Health Disparities, Healthcare Implementation, Immunity, Immunology, Host Factors, Host Response, Oral Science / Dentistry, Organ, Oral Cavity, Prevention, Product Development and Commercialization, Prognostics, Research Methods, Cell Culture, Electronic Health Records (EHR), Imaging, Immunofluorescence, Screen, Sequencing, Research Model Development, Research Models, Mouse Models, Non-Human Animal Models, Virology, Viral Interactome, Viral Proteins, Virus Biology, Virus Evolution, Virus Factors, Vaccine Development, Vaccine Efficacy, Vaccine Reliability, Vaccine Scalability, Research Tool Development, Treatments, Treatment Efficacy, Treatment Reliability, Treatment Scalability, Drugs, Antibody-based Treatment, Drug Development, Drug Repurposing, Drug Targets, Immunological Response Targets, Anti-viral Targets