This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to participate in the Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern program. The purpose of this program is to support comprehensive multidisciplinary research Centers focused on innovative antiviral drug development targeting coronaviruses (CoVs), emphasizing SARS-CoV-2, and one or more select RNA viruses with pandemic potential. NIAID is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS, for the 2019 Novel Coronavirus (COVID-19), and within the provisions described in the "American Rescue Plan Act of 2021."