This Notice of Special Interest (NOSI) invites applications for administrative supplements to NIMHD Research Centers in Minority Institutions (RCMI) U54 awards to support pilot research projects led by early-stage investigators (ESIs) and new investigators (NIs) focused on research on substance use, addiction, and/or neuroscience, as a bridge to independently funded careers. It is expected that pilot project PIs will work with their institutions to prepare and submit follow-up research grant or career development applications to NIH based on the research supported by these supplemental funds